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Clinically validated examples of in silico and structure-based approaches contributing directly to approved therapeutics include the development of HIV protease inhibitors in the 1990sthe first drugs designed using computational structureactivity relationshipsand the more recent application of GPCR crystal structures to guide ligand optimization for receptors, including the 2-adrenoceptor and GLP-1 receptor ( These tools enable peptide systems to be evaluated with a level of mechanistic precision unavailable when many were first investigated

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Later, melanotan-II was synthesised